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Manual article review is required for this article
Manual article review is required for this article
Wham clusters every one of the candidate breakpoints and rounds their positions to the closest tenth base pair. The placement with the best examine assist is reported. When the comfortable-clipped consensus sequence might be aligned into the putative breakpoint location utilizing the Smith-Waterman algorithm, the breakpoint is more refined to The p
Wham is made for paired-finish Illumina libraries with common insert sizes (~300bp-500bp). Wham integrates mate-pair mapping, break up examine mapping, gentle-clipping, different alignment and consensus sequence based proof to predict SV breakpoints with single-nucleotide accuracy. Wham generates a merged pileup (catalog of reads covering a positio